Activated Phosphatidylinositol 3-Kinase/Akt Inhibits the Transition of Endothelial Progenitor Cells to Mesenchymal Cells by Regulating the Forkhead Box Subgroup O-3a Signaling | Zendy

Zongqi Zhang | Zendy; Tiantian Zhang | Zendy; Yaoyao Zhou | Zendy; Xiaowei Wei | Zendy; Jianbing Zhu | Zendy; Junfeng Zhang | Zendy; Changqian Wang | Zendy

Open Access

Activated Phosphatidylinositol 3-Kinase/Akt Inhibits the Transition of Endothelial Progenitor Cells to Mesenchymal Cells by Regulating the Forkhead Box Subgroup O-3a Signaling

Author(s) -

Zongqi Zhang,

Tiantian Zhang,

Yaoyao Zhou,

Xiaowei Wei,

Jianbing Zhu,

Junfeng Zhang,

Changqian Wang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000373978

Subject(s) - small hairpin rna , protein kinase b , progenitor cell , pi3k/akt/mtor pathway , endothelial progenitor cell , microbiology and biotechnology , chemistry , mesenchymal stem cell , western blot , signal transduction , biology , cancer research , stem cell , gene knockdown , apoptosis , biochemistry , gene

Endothelial progenitor cells (EPCs) differentiate into mature endothelial cells and may thus be candidates for ischemic disease therapy; however, the transition of EPCs to mesenchymal cells is not fully understood. We explored the role of phosphatidylinositol 3-kinase (PI3K)/Akt signaling in endothelial-to-mesenchymal transition (EndMT) induced by transforming growth factor beta 1 (TGF-β1).

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