Calcium Sensing Receptor Regulating Smooth Muscle Cells Proliferation Through Initiating Cystathionine-Gamma-Lyase/Hydrogen Sulfide Pathway in Diabetic Rat | Zendy

Xin Zhong | Zendy; Yuwen Wang | Zendy; Jichao Wu | Zendy; Aili Sun | Zendy; Fan Yang | Zendy; Dan Zheng | Zendy; Ting Li | Zendy; Shiyun Dong | Zendy; Yajun Zhao | Zendy; Guangdong Yang | Zendy; Changqing Xu | Zendy; Dianjun Sun | Zendy; Fanghao Lu | Zendy; Weihua Zhang | Zendy

Open Access

Calcium Sensing Receptor Regulating Smooth Muscle Cells Proliferation Through Initiating Cystathionine-Gamma-Lyase/Hydrogen Sulfide Pathway in Diabetic Rat

Author(s) -

Xin Zhong,

Yuwen Wang,

Jichao Wu,

Aili Sun,

Fan Yang,

Dan Zheng,

Ting Li,

Shiyun Dong,

Yajun Zhao,

Guangdong Yang,

Changqing Xu,

Dianjun Sun,

Fanghao Lu,

Weihua Zhang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000373973

Subject(s) - vascular smooth muscle , calcium sensing receptor , medicine , endocrinology , sodium hydrosulfide , chemistry , calcium in biology , receptor , mesenteric arteries , calmodulin , cystathionine beta synthase , blot , microbiology and biotechnology , calcium , biology , biochemistry , calcium metabolism , enzyme , artery , hydrogen sulfide , sulfur , organic chemistry , cysteine , smooth muscle , gene

Hydrogen sulfide (H₂S) inhibits the proliferation of vascular smooth muscle cells (VSMCs). However, how cystathionine-gamma-lyase (CSE), a major enzyme that produces H₂S, is regulated remains unknown. Whether calcium-sensing receptor (CaSR) inhibits the proliferation of VSMCs by regulating the endogenous CSE/H₂S pathway in diabetic rat has not been previously investigated.

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