Enhancement of LPS-Induced Microglial Inflammation Response via TLR4 Under High Glucose Conditions | Zendy

Xiang Zhang | Zendy; Hongquan Dong | Zendy; Susu Zhang | Zendy; Shunmei Lu | Zendy; Jie Sun | Zendy; Yanning Qian | Zendy

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Enhancement of LPS-Induced Microglial Inflammation Response via TLR4 Under High Glucose Conditions

Author(s) -

Xiang Zhang,

Hongquan Dong,

Susu Zhang,

Shunmei Lu,

Jie Sun,

Yanning Qian

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000373972

Subject(s) - neuroinflammation , microglia , tlr4 , inflammation , cytokine , endocrinology , signal transduction , diabetes mellitus , medicine , lipopolysaccharide , tumor necrosis factor alpha , chemistry , biochemistry

Microglia activation mediated by toll-like receptor 4 (TLR4) plays an important role in neuroinflammation and postoperative cognitive dysfunction (POCD). Diabetes mellitus (DM) has been recently suggested as an independent risk factor for POCD. In this study, we investigate the potential exacerbation of the inflammatory response in primary microglia due to high glucose conditions.

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