MiR-301a Mediates the Effect of IL-6 on the AKT/GSK Pathway and Hepatic Glycogenesis by Regulating PTEN Expression | Zendy

Xin Lin | Zendy; Shuyue Wang | Zendy; Xiaofang Sui | Zendy; Xiangyu Meng | Zendy; Tao Shen | Zendy; Xiuqing Huang | Zendy; Jun Guo | Zendy; Weiwei Fang | Zendy; Yong Man | Zendy; Jianzhong Xi | Zendy; Jian Li | Zendy

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MiR-301a Mediates the Effect of IL-6 on the AKT/GSK Pathway and Hepatic Glycogenesis by Regulating PTEN Expression

Author(s) -

Xin Lin,

Shuyue Wang,

Xiaofang Sui,

Xiangyu Meng,

Tao Shen,

Xiuqing Huang,

Jun Guo,

Weiwei Fang,

Yong Man,

Jianzhong Xi,

Jian Li

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000373962

Subject(s) - pten , glycogenesis , protein kinase b , biology , cancer research , insulin resistance , signal transduction , microbiology and biotechnology , medicine , glycogen synthase , endocrinology , pi3k/akt/mtor pathway , phosphorylation , insulin

IL-6 has been implicated in the pathogenesis of insulin resistance. MiR-301a plays an important role in various biological and pathological processes, including cellular development and differentiation, inflammation, apoptosis and cancer. However, whether miR-301a mediates IL-6-induced insulin resistance in hepatocytes remains unknown.

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