Early Secreted Antigen ESAT-6 of Mycobacterium Tuberculosis Promotes Apoptosis of Macrophages via Targeting the MicroRNA155-SOCS1 Interaction | Zendy

Shaojun Yang | Zendy; Fake Li | Zendy; Shuangrong Jia | Zendy; Kejun Zhang | Zendy; Wenbing Jiang | Zendy; Ya M Shang | Zendy; Kai Chang | Zendy; Shaoli Deng | Zendy; Ming Chen | Zendy

Open Access

Early Secreted Antigen ESAT-6 of Mycobacterium Tuberculosis Promotes Apoptosis of Macrophages via Targeting the MicroRNA155-SOCS1 Interaction

Author(s) -

Shaojun Yang,

Fake Li,

Shuangrong Jia,

Kejun Zhang,

Wenbing Jiang,

Ya M Shang,

Kai Chang,

Shaoli Deng,

Ming Chen

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000373950

Subject(s) - esat 6 , tlr2 , suppressor of cytokine signaling 1 , biology , mycobacterium tuberculosis , macrophage , apoptosis , immune system , immunology , innate immune system , tuberculosis , medicine , in vitro , biochemistry , genetics , pathology , cancer , suppressor

The early secreted antigenic target 6-kDa protein (ESAT-6) of Mycobacterium tuberculosis (Mtb) not only acts as a key player for virulence but also exhibits a strong immunotherapeutic potential against Mtb. However, little is known about the molecular basis for its potential in immunotherapy. The present study was designed to unravel the role of miRNA-155 in ESAT-6-mediated enhancement of host immunity and apoptosis in macrophages.

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