Induction of Haemeoxygenase-1 Improves FFA-Induced Endothelial Dysfunction in Rat Aorta | Zendy

Fang Han | Zendy; Zongguang Hui | Zendy; Shuxian Zhang | Zendy; Ningning Hou | Zendy; Yali Wang | Zendy; Xiaodong Sun | Zendy

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Induction of Haemeoxygenase-1 Improves FFA-Induced Endothelial Dysfunction in Rat Aorta

Author(s) -

Fang Han,

Zongguang Hui,

Shuxian Zhang,

Ningning Hou,

Yali Wang,

Xiaodong Sun

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000373946

Subject(s) - copp , medicine , endocrinology , enos , ampk , nitric oxide , endothelial dysfunction , heme oxygenase , chemistry , malondialdehyde , endothelium , prostacyclin , nitric oxide synthase , protein kinase a , oxidative stress , kinase , biochemistry , heme , enzyme

The induction of haemeoxygenase-1 (HO-1) exerts beneficial effects in the setting of endothelial dysfunction in obesity. High free fatty acid (FFA) levels are a common feature of obesity and are the primary cause of endothelial dysfunction. The objective of our study was to explore the effects of HO-1 induction on FFA-induced endothelial dysfunction in rats.

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