Mitomycin C Induces Apoptosis in Rheumatoid Arthritis Fibroblast-Like Synoviocytes via a Mitochondrial-Mediated Pathway | Zendy

Chuqi Yan | Zendy; Dechao Kong | Zendy; Ge Dong | Zendy; Yanming Zhang | Zendy; Xishan Zhang | Zendy; Changhui Su | Zendy; Xiaojian Cao | Zendy

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Mitomycin C Induces Apoptosis in Rheumatoid Arthritis Fibroblast-Like Synoviocytes via a Mitochondrial-Mediated Pathway

Author(s) -

Chuqi Yan,

Dechao Kong,

Ge Dong,

Yanming Zhang,

Xishan Zhang,

Changhui Su,

Xiaojian Cao

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000373938

Subject(s) - apoptosis , viability assay , cytochrome c , fibroblast , annexin , microbiology and biotechnology , programmed cell death , cell growth , biology , chemistry , cell culture , biochemistry , genetics

Rheumatoid arthritis (RA) is a systemic chronic inflammatory disease characterised by prominent synoviocyte hyperplasia and a potential imbalance between the growth and death of fibroblast-like synoviocytes (FLS). Mitomycin C (MMC) has previously been demonstrated to inhibit fibroblast proliferation and to induce fibroblast apoptosis. However, the effects of MMC on the proliferation and apoptosis of human RA FLS and the potential mechanisms underlying its effects remain unknown.

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