SIRT1 Suppresses Doxorubicin-Induced Cardiotoxicity by Regulating the Oxidative Stress and p38MAPK Pathways | Zendy

Yang Ruan | Zendy; Chunlin Dong | Zendy; J. Patel | Zendy; Chao Duan | Zendy; Xinyue Wang | Zendy; Xi Wu | Zendy; Yuan Cao | Zendy; Lianmei Pu | Zendy; Dan Lu | Zendy; Tao Shen | Zendy; Jian Li | Zendy

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SIRT1 Suppresses Doxorubicin-Induced Cardiotoxicity by Regulating the Oxidative Stress and p38MAPK Pathways

Author(s) -

Yang Ruan,

Chunlin Dong,

J. Patel,

Chao Duan,

Xinyue Wang,

Xi Wu,

Yuan Cao,

Lianmei Pu,

Dan Lu,

Tao Shen,

Jian Li

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000373937

Subject(s) - doxorubicin , sirtuin 1 , sirtuin , resveratrol , apoptosis , oxidative stress , biology , reactive oxygen species , tunel assay , microbiology and biotechnology , cardiotoxicity , myocyte , dna laddering , programmed cell death , pharmacology , cancer research , nad+ kinase , endocrinology , downregulation and upregulation , medicine , biochemistry , enzyme , toxicity , chemotherapy , dna fragmentation , gene

SIRT1, which belongs to the Sirtuin family of NAD-dependent enzymes, plays diverse roles in aging, metabolism, and disease biology. It could regulate cell survival and has been shown to be a protective factor in heart function. Hence, we verified the mechanism by which SIRT1 regulates doxorubicin induced cardiomyocyte injury in vivo and in vitro.

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