LXR Agonist T0901317-Induced Hyperlipidemia Does Not Lead to Lipid Accumulation in the Rat Heart | Zendy

Dorota Harasiuk | Zendy; Marcin Baranowski | Zendy; Piotr Zabielski | Zendy; Adrian Chabowski | Zendy; J Górski | Zendy

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LXR Agonist T0901317-Induced Hyperlipidemia Does Not Lead to Lipid Accumulation in the Rat Heart

Author(s) -

Dorota Harasiuk,

Marcin Baranowski,

Piotr Zabielski,

Adrian Chabowski,

J Górski

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000373935

Subject(s) - liver x receptor , medicine , endocrinology , agonist , hyperlipidemia , cholesterol , lipid metabolism , fenofibrate , chemistry , receptor , biology , nuclear receptor , transcription factor , biochemistry , diabetes mellitus , gene

Liver X receptors (LXRα and LXRβ) are ligand-activated transcription factors that regulate expression of genes involved in lipid and cholesterol metabolism. LXR expression has been identified in human and rodent cardiac tissue, however, its role in this tissue remains unclear. The aim of this study was to investigate effects of in vivo LXR activation on lipid metabolism in the rat myocardium under the conditions of low and high lipid intake.

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