Regulation of Renal Fibrosis by Macrophage Polarization | Zendy

Bixia Pan | Zendy; Guohui Liu | Zendy; Zongpei Jiang | Zendy; Dongwen Zheng | Zendy

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Regulation of Renal Fibrosis by Macrophage Polarization

Author(s) -

Bixia Pan,

Guohui Liu,

Zongpei Jiang,

Dongwen Zheng

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000373932

Subject(s) - fibrosis , macrophage , medicine , epithelial–mesenchymal transition , renal stem cell , macrophage polarization , kidney , cancer research , pathology , transplantation , m2 macrophage , transforming growth factor , flow cytometry , immunology , biology , microbiology and biotechnology , stem cell , cancer , progenitor cell , biochemistry , in vitro , metastasis

Since renal fibrosis always predisposes end-stage renal disease, elucidation of the molecular mechanisms that underlie the progression of renal fibrosis may substantially improve the understanding and treatment for renal failure. Previous studies have highlighted an important counteraction between transforming growth factor β 1 (TGFβ1) and bone morphogenic protein 7 (BMP7) in the epithelial-to-mesenchymal transition (EMT) of renal tubular epithelial cells during chronic renal injury. Macrophages are also believed to play a critical role in renal fibrosis. However, the relationship between macrophages and EMT is unknown.

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