Monkeys and Rats Are Not Susceptible to Ferret Hepatitis E Virus Infection | Zendy

TianCheng Li | Zendy; Sayaka Yoshizaki | Zendy; Yasushi Ami | Zendy; Yuriko Suzaki | Zendy; Tingting Yang | Zendy; Naokazu Takeda | Zendy; Takaji Wakita | Zendy

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Monkeys and Rats Are Not Susceptible to Ferret Hepatitis E Virus Infection

Author(s) -

TianCheng Li,

Sayaka Yoshizaki,

Yasushi Ami,

Yuriko Suzaki,

Tingting Yang,

Naokazu Takeda,

Takaji Wakita

Publication year - 2015

Publication title -

intervirology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.641

H-Index - 61

eISSN - 1423-0100

pISSN - 0300-5526

DOI - 10.1159/000373891

Subject(s) - virology , hepatitis e virus , virus , biology , viral replication , hepatitis , viral shedding , immunology , genotype , biochemistry , gene

Ferret hepatitis E virus (HEV), a novel hepatitis E-like virus, has been identified in ferrets in the Netherlands, Japan, and the US. To determine whether ferret HEV transmits to other animals, we inoculated laboratory rats (Wistar), nude rats (Long-Evans-rnu/rnu), and cynomolgus monkeys with ferret HEV (F4351) by intravenous injection. None of the animals demonstrated a positive sign for virus replication, indicating that rats and monkeys are not susceptible to ferret HEV.

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