Recombinant Human Growth Hormone Plus Recombinant Human Insulin-Like Growth Factor-1 Coadministration Therapy in Short Children with Low Insulin-Like Growth Factor-1 and Growth Hormone Sufficiency: Results from a Randomized, Multicenter, Open-Label, Parallel-Group, Active Treatment-Controlled Trial | Zendy

Philippe Backeljauw | Zendy; Bradley S. Miller | Zendy; Pascale Dutailly | Zendy; Aude Houchard | Zendy; Elizabeth A. Lawson | Zendy; Daniel E. Hale | Zendy; Barry Reiner | Zendy; Mark A. Sperling | Zendy

Open Access

Recombinant Human Growth Hormone Plus Recombinant Human Insulin-Like Growth Factor-1 Coadministration Therapy in Short Children with Low Insulin-Like Growth Factor-1 and Growth Hormone Sufficiency: Results from a Randomized, Multicenter, Open-Label, Parallel-Group, Active Treatment-Controlled Trial

Author(s) -

Philippe Backeljauw,

Bradley S. Miller,

Pascale Dutailly,

Aude Houchard,

Elizabeth A. Lawson,

Daniel E. Hale,

Barry Reiner,

Mark A. Sperling

Publication year - 2015

Publication title -

hormone research in paediatrics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.816

H-Index - 89

eISSN - 1663-2826

pISSN - 1663-2818

DOI - 10.1159/000371799

Subject(s) - medicine , endocrinology , insulin like growth factor , idiopathic short stature , randomized controlled trial , insulin , short stature , growth factor , adverse effect , population , growth hormone treatment , recombinant dna , growth hormone , hormone , biology , receptor , biochemistry , gene , environmental health

Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) both contribute to growth. To determine if recombinant human (rh)GH + rhIGF-1 therapy is more effective than rhGH alone to treat short stature, we assessed the efficacy and safety of coadministered rhGH + rhIGF-1 in short children with GH sufficiency and low IGF-1.

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