High IFN-&#947;/IL-10 Expression Ratio and Increased Frequency of Persistent Human T-Cell Lymphotropic Virus Type 1-Infected Clones Are Associated with Human T-Cell Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis Development | Zendy

Otávio de Melo Espíndola | Zendy; Luã C. Oliveira | Zendy; Priscilla M.S. Ferreira | Zendy; Ana Claúdia Celestino Bezerra Leite | Zendy; Marco Antônio Lima | Zendy; Maria José AndradaSerpa | Zendy

Open Access

High IFN-γ/IL-10 Expression Ratio and Increased Frequency of Persistent Human T-Cell Lymphotropic Virus Type 1-Infected Clones Are Associated with Human T-Cell Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis Development

Author(s) -

Otávio de Melo Espíndola,

Luã C. Oliveira,

Priscilla M.S. Ferreira,

Ana Claúdia Celestino Bezerra Leite,

Marco Antônio Lima,

Maria José AndradaSerpa

Publication year - 2015

Publication title -

intervirology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.641

H-Index - 61

eISSN - 1423-0100

pISSN - 0300-5526

DOI - 10.1159/000371766

Subject(s) - tropical spastic paraparesis , provirus , virology , human t lymphotropic virus , retrovirus , human t lymphotropic virus 1 , biology , virus , microbiology and biotechnology , medicine , gene , myelopathy , biochemistry , genome , neuroscience , spinal cord , t cell leukemia

Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that causes a persistent infection, and only 0.5-5% of infected individuals will develop HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Therefore, we investigated parameters to discriminate HTLV-1 asymptomatic carriers (ACs) with an increased chance to develop HAM/TSP.

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