Impact of in vitro Costimulation with TLR2, TLR4 and TLR9 Agonists and HIV-1 on Antigen-Presenting Cell Activation | Zendy

Diana M. Giraldo | Zendy; Juan C. Hernández | Zendy; Silvio UrcuquiInchima | Zendy

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Impact of in vitro Costimulation with TLR2, TLR4 and TLR9 Agonists and HIV-1 on Antigen-Presenting Cell Activation

Author(s) -

Diana M. Giraldo,

Juan C. Hernández,

Silvio UrcuquiInchima

Publication year - 2015

Publication title -

intervirology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.641

H-Index - 61

eISSN - 1423-0100

pISSN - 0300-5526

DOI - 10.1159/000371765

Subject(s) - tlr9 , chemistry , antigen , in vitro , microbiology and biotechnology , tlr4 , tlr2 , virology , receptor , biology , immunology , biochemistry , gene , gene expression , dna methylation

HIV-1 infects several immune cells including dendritic cells (DCs) and monocytes, which contributes in both to dissemination of HIV-1 infection and induction of antiviral immunity. These cells produce high amounts of type I IFN and proinflammatory cytokines upon Toll-like receptor (TLR) stimulation. During HIV-1 infection, an altered production of proinflammatory cytokines has been reported. However, the mechanisms underlying cytokine modulation have not been well described. Here, we evaluated the production of proinflammatory cytokines and activation of myeloid and plasmacytoid DCs and monocytes costimulated in vitro with TLR agonists and HIV-1.

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