Lipoxin A4 Mediates Aortic Contraction via RHOA/RHO Kinase, Endothelial Dysfunction and Reactive Oxygen Species | Zendy

Camilla F. Wenceslau | Zendy; Cameron G. McCarthy | Zendy; Theodora Szasz | Zendy; R. Clinton Webb | Zendy

Open Access

Lipoxin A<sub>4</sub> Mediates Aortic Contraction via RHOA/RHO Kinase, Endothelial Dysfunction and Reactive Oxygen Species

Author(s) -

Camilla F. Wenceslau,

Cameron G. McCarthy,

Theodora Szasz,

R. Clinton Webb

Publication year - 2014

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000371490

Subject(s) - apocynin , chemistry , nadph oxidase , reactive oxygen species , endocrinology , medicine , biochemistry , biology

Lipoxin A4 (LXA4) is a biologically active product generated from arachidonic acid by lipoxygenase action. The production of lipoxins is enhanced by aspirin through acetylation of cyclooxygenase-2, via a mechanism known as 'aspirin-triggered lipoxin'. LXA4 has both anti-inflammatory and proinflammatory actions, the latter being related with reocclusion and restenosis after coronary angioplasty in patients treated with aspirin. However, little is known of the actions of LXA4 on the vasculature. We hypothesized that LXA4 promotes contractile responses and contributes to endothelial dysfunction.

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