Open AccessIdiopathic Calcium Nephrolithiasis: A Review of Pathogenic Mechanisms in the Light of Genetic Studies
Author(s) -
Teresa Arcidiacono,
Alessandra Mingione,
Lorenza Macrina,
Francesca Pivari,
Laura Soldati,
Giuseppe Vezzoli
Publication year - 2014
Publication title -
american journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 85
eISSN - 1421-9670
pISSN - 0250-8095
DOI - 10.1159/000369833
Subject(s) - calcium oxalate , calcium , medicine , endocrinology , kidney stones
Calcium nephrolithiasis is a multifactorial disease with a polygenic milieu. Association studies identified genetic polymorphisms potentially implicated in the pathogenesis of calcium nephrolithiasis. The present article reviews the mechanisms of calcium stone formation and the potential contribution of gene polymorphisms to lithogenic mechanisms.
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