MiR-144 Inhibits Proliferation and Induces Apoptosis and Autophagy in Lung Cancer Cells by Targeting TIGAR | Zendy

Shanshan Chen | Zendy; Ping Li | Zendy; Juan Li | Zendy; Yuanyuan Wang | Zendy; Yuwen Du | Zendy; Xiaonan Chen | Zendy; Wenqiao Zang | Zendy; Huaqi Wang | Zendy; Heying Chu | Zendy; Guoqiang Zhao | Zendy; Guojun Zhang | Zendy

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MiR-144 Inhibits Proliferation and Induces Apoptosis and Autophagy in Lung Cancer Cells by Targeting TIGAR

Author(s) -

Shanshan Chen,

Ping Li,

Juan Li,

Yuanyuan Wang,

Yuwen Du,

Xiaonan Chen,

Wenqiao Zang,

Huaqi Wang,

Heying Chu,

Guoqiang Zhao,

Guojun Zhang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000369755

Subject(s) - microrna , apoptosis , biology , flow cytometry , cell growth , microbiology and biotechnology , a549 cell , autophagy , microarray analysis techniques , cancer research , gene expression , reporter gene , gene , genetics

MiRNAs are noncoding RNAs of 20-24 nucleotides that function as post-transcriptional negative regulators of gene expression. MiRNA genes are usually transcribed by RNA polymerase II in the nucleus. Their initial products are pre-miRNAs which have cap sequences and polyA tails. The p53-induced glycolysis and apoptosis regulator (TIGAR) was discovered through microarray analysis of gene expression following activation of p53. However, little is known about the effect of miR-144 on cell proliferation and apoptosis and how it interacts with TIGAR.

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