GOLPH3 Overexpression is Closely Correlated with Poor Prognosis in Human Non-Small Cell Lung Cancer and Mediates its Metastasis Through Upregulating MMP-2 and MMP-9 | Zendy

Ran Wang | Zendy; Zunfu Ke | Zendy; Fen Wang | Zendy; Wenhui Zhang | Zendy; Yuefeng Wang | Zendy; Shuhua Li | Zendy; Liantang Wang | Zendy

Open Access

GOLPH3 Overexpression is Closely Correlated with Poor Prognosis in Human Non-Small Cell Lung Cancer and Mediates its Metastasis Through Upregulating MMP-2 and MMP-9

Author(s) -

Ran Wang,

Zunfu Ke,

Fen Wang,

Wenhui Zhang,

Yuefeng Wang,

Shuhua Li,

Liantang Wang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000369753

Subject(s) - gene knockdown , metastasis , oncogene , biology , cancer research , lung cancer , phosphoprotein , matrix metalloproteinase , gentamicin protection assay , immunohistochemistry , small interfering rna , cancer , cell culture , oncology , medicine , transfection , immunology , cell cycle , phosphorylation , microbiology and biotechnology , genetics

Golgi phosphoprotein 3 (GOLPH3) is a newly reported oncogene that plays a significant role in regulating cell growth. Recent research has shown that overexpression of GOLPH3 is correlated with patient survival and M classification in breast cancer and other cancers. However, the mechanisms by which GOLPH3 contributes to metastasis in non-small cell lung cancer (NSCLC) have not been previously clarified and are therefore the focus of this work.

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