Pioglitazone Lowers Serum Retinol Binding Protein 4 by Suppressing its Expression in Adipose Tissue of Obese Rats | Zendy

Chaoyu Zhu | Zendy; Yuanyuan Xiao | Zendy; Xiaohua Liu | Zendy; Junfeng Han | Zendy; Jianmei Zhang | Zendy; Wei Li | Zendy; Weiping Jia | Zendy

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Pioglitazone Lowers Serum Retinol Binding Protein 4 by Suppressing its Expression in Adipose Tissue of Obese Rats

Author(s) -

Chaoyu Zhu,

Yuanyuan Xiao,

Xiaohua Liu,

Junfeng Han,

Jianmei Zhang,

Wei Li,

Weiping Jia

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000369737

Subject(s) - pioglitazone , medicine , endocrinology , adipose tissue , retinol binding protein 4 , insulin resistance , peroxisome proliferator activated receptor , insulin , diabetes mellitus , receptor , type 2 diabetes , adipokine

Pioglitazone, a peroxisome proliferator-activated receptor γ activator, is clinically used to treat insulin resistance. However, the underlying mechanism of pioglitazone's action remains unclear. We investigated whether, and how, pioglitazone modulates serum level of retinol binding protein 4 (RBP4), an adipocytokine associated with obesity and insulin resistance.

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