Calycosin and Genistein Induce Apoptosis by Inactivation of HOTAIR/p-Akt Signaling Pathway in Human Breast Cancer MCF-7 Cells | Zendy

Jian Chen | Zendy; Changrong Lin | Zendy; Yong Wang | Zendy; Yu Ye | Zendy; Zhaoquan Huang | Zendy

Open Access

Calycosin and Genistein Induce Apoptosis by Inactivation of HOTAIR/p-Akt Signaling Pathway in Human Breast Cancer MCF-7 Cells

Author(s) -

Jian Chen,

Changrong Lin,

Yong Wang,

Yu Ye,

Zhaoquan Huang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000369732

Subject(s) - calycosin , genistein , hotair , mcf 7 , protein kinase b , cancer research , apoptosis , cell growth , pi3k/akt/mtor pathway , signal transduction , chemistry , cancer cell , cancer , biology , pharmacology , medicine , endocrinology , downregulation and upregulation , biochemistry , formononetin , daidzein , human breast , long non coding rna , gene

Calycosin and genistein are the two main components of isoflavones. Previously, we reported that these compounds display antitumor activities in the breast cancer cell lines MCF-7 and T47D. In the present study, we investigated the mechanism of action of calycosin and genistein, and their respective efficacies as potential therapies for the treatment of breast carcinoma in the clinic.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research