Biochanin A Promotes Proliferation that Involves a Feedback Loop of MicroRNA-375 and Estrogen Receptor Alpha in Breast Cancer Cells | Zendy

Jian Chen | Zendy; Bo Ge | Zendy; Yong Wang | Zendy; Ye Yu | Zendy; Sien Zeng | Zendy; Zhaoquan Huang | Zendy

Open Access

Biochanin A Promotes Proliferation that Involves a Feedback Loop of MicroRNA-375 and Estrogen Receptor Alpha in Breast Cancer Cells

Author(s) -

Jian Chen,

Bo Ge,

Yong Wang,

Ye Yu,

Sien Zeng,

Zhaoquan Huang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000369725

Subject(s) - biochanin a , formononetin , cell growth , estrogen receptor , estrogen receptor alpha , cancer research , apoptosis , mcf 7 , in vivo , isoflavones , downregulation and upregulation , cell , chemistry , biology , cancer , cancer cell , breast cancer , medicine , endocrinology , biochemistry , genistein , daidzein , human breast , microbiology and biotechnology , gene

Biochanin A and formononetin are O-methylated isoflavones that are isolated from the root of Astragalus membranaceus, and have antitumorigenic effects. Our previous studies found that formononetin triggered growth-inhibitory and apoptotic activities in MCF-7 breast cancer cells. We performed in vivo and in vitro studies to further investigate the potential effect of biochanin A in promoting cell proliferation in estrogen receptor (ER)-positive cells, and to elucidate underlying mechanisms.

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