Amino-Nogo Inhibits Optic Nerve Regeneration and Functional Recovery via the Integrin αv Signaling Pathway in Rats | Zendy

Yan Huo | Zendy; Xiaolei Yin | Zendy; Shu-Xing Ji | Zendy; Huan Zou | Zendy; Min Lang | Zendy; Zheng Zheng | Zendy; Xiaofeng Cai | Zendy; Wei Liu | Zendy; Chun-Lin Chen | Zendy; YuanGuo Zhou | Zendy; Rongdi Yuan | Zendy; Jian Ye | Zendy

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Amino-Nogo Inhibits Optic Nerve Regeneration and Functional Recovery via the Integrin αv Signaling Pathway in Rats

Author(s) -

Yan Huo,

Xiaolei Yin,

Shu-Xing Ji,

Huan Zou,

Min Lang,

Zheng Zheng,

Xiaofeng Cai,

Wei Liu,

Chun-Lin Chen,

YuanGuo Zhou,

Rongdi Yuan,

Jian Ye

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000369723

Subject(s) - integrin , focal adhesion , axon , optic nerve , regeneration (biology) , retinal ganglion cell , microbiology and biotechnology , chemistry , signal transduction , biology , neuroscience , cell , biochemistry

Nogo-A, a major myelin-associated inhibitor, can inhibit injured optic nerve regeneration. However, whether Amino-Nogo is the most important functional domain of Nogo-A remains unknown. This study aimed to identify the role of Amino-Nogo following optic nerve injury, and the mechanism of the Amino-Nogo-integrin αv signaling pathway in vivo.

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