Stimulation of Suicidal Erythrocyte Death by PRIMA-1 | Zendy

Caterina Faggio | Zendy; Kousi Alzoubi | Zendy; Salvatrice Calabrò | Zendy; Florian Läng | Zendy

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Stimulation of Suicidal Erythrocyte Death by PRIMA-1

Author(s) -

Caterina Faggio,

Kousi Alzoubi,

Salvatrice Calabrò,

Florian Läng

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000369717

Subject(s) - phosphatidylserine , ceramide , apoptosis , programmed cell death , annexin , microbiology and biotechnology , cytosol , annexin a5 , extracellular , biology , chemistry , biochemistry , membrane , phospholipid , enzyme

The anticarcinogenic drug PRIMA-1 (p53 reactivation and induction of massive apoptosis 1) induces suicidal death of tumor cells, an effect in large part attributed to the up-regulation of the proapoptotic transcription factor p53. Erythrocytes are lacking gene transcription but are nevertheless able to enter eryptosis, a suicidal erythrocyte death characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Stimulators of eryptosis include increase of cytosolic Ca(2+)-activity ([Ca(2+)]i) and ceramide formation. The present study tested whether PRIMA-1 stimulates eryptosis.

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