A Dysregulated MicroRNA-26a/EphA2 Axis Impairs Endothelial Progenitor Cell Function via the p38 MAPK/VEGF Pathway | Zendy

Keqiang Zuo | Zendy; Kangkang Zhi | Zendy; Xiaoping Zhang | Zendy; Chenghui Lu | Zendy; Shi Wang | Zendy; Maoquan Li | Zendy; Bin He | Zendy

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A Dysregulated MicroRNA-26a/EphA2 Axis Impairs Endothelial Progenitor Cell Function via the p38 MAPK/VEGF Pathway

Author(s) -

Keqiang Zuo,

Kangkang Zhi,

Xiaoping Zhang,

Chenghui Lu,

Shi Wang,

Maoquan Li,

Bin He

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000369713

Subject(s) - gene knockdown , progenitor cell , microrna , cancer research , mapk/erk pathway , downregulation and upregulation , endothelial progenitor cell , eph receptor a2 , viability assay , p38 mitogen activated protein kinases , medicine , blot , mtt assay , cell , biology , signal transduction , microbiology and biotechnology , stem cell , cell culture , biochemistry , genetics , gene , receptor tyrosine kinase

Dysfunction of circulating endothelial progenitor cells (EPCs) is associated with the onset of cardiovascular disorders. Circulating microRNAs (miRNAs) have been recognized as novel biomarkers and potential therapeutic targets. Here, we examined the role of miR-26a overexpression in atherosclerosis and explored the underlying mechanisms.

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