Anti-Cancer Effect of Metabotropic Glutamate Receptor 1 Inhibition in Human Glioma U87 Cells: Involvement of PI3K/Akt/mTOR Pathway | Zendy

Chi Zhang | Zendy; Xianrui Yuan | Zendy; Haoyu Li | Zendy; Zijin Zhao | Zendy; Yiwei Liao | Zendy; Xiangyu Wang | Zendy; Jun Su | Zendy; Shushan Sang | Zendy; Qing Liu | Zendy

Open Access

Anti-Cancer Effect of Metabotropic Glutamate Receptor 1 Inhibition in Human Glioma U87 Cells: Involvement of PI3K/Akt/mTOR Pathway

Author(s) -

Chi Zhang,

Xianrui Yuan,

Haoyu Li,

Zijin Zhao,

Yiwei Liao,

Xiangyu Wang,

Jun Su,

Shushan Sang,

Qing Liu

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000369707

Subject(s) - metabotropic glutamate receptor 1 , pi3k/akt/mtor pathway , protein kinase b , viability assay , metabotropic glutamate receptor , chemistry , glioma , cancer cell , microbiology and biotechnology , cancer research , biology , pharmacology , glutamate receptor , signal transduction , apoptosis , receptor , biochemistry , cancer , genetics

Metabotropic glutamate receptors (mGluRs) are G-protein-coupled receptors that mediate neuronal excitability and synaptic plasticity in the central nervous system, and emerging evidence suggests a role of mGluRs in the biology of cancer. Previous studies showed that mGluR1 was a potential therapeutic target for the treatment of breast cancer and melanoma, but its role in human glioma has not been determined.

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