AMP-Activated Protein Kinase α1 Regulates Cardiac Gap Junction Protein Connexin 43 and Electrical Remodeling Following Pressure Overload | Zendy

Ioana Alesutan | Zendy; Jakob Voelkl | Zendy; Florian Stöckigt | Zendy; Sobuj Mia | Zendy; Martina Feger | Zendy; Uwe Primeßnig | Zendy; Mentor Sopjani | Zendy; Carlos Muñoz | Zendy; Oliver Borst | Zendy; Meinrad Gawaz | Zendy; Burkert Pieske | Zendy; Bernhard Metzler | Zendy; Frank R. Heinzel | Zendy; Jan W. Schrickel | Zendy; Florian Läng | Zendy

Open Access

AMP-Activated Protein Kinase α1 Regulates Cardiac Gap Junction Protein Connexin 43 and Electrical Remodeling Following Pressure Overload

Author(s) -

Ioana Alesutan,

Jakob Voelkl,

Florian Stöckigt,

Sobuj Mia,

Martina Feger,

Uwe Primeßnig,

Mentor Sopjani,

Carlos Muñoz,

Oliver Borst,

Meinrad Gawaz,

Burkert Pieske,

Bernhard Metzler,

Frank R. Heinzel,

Jan W. Schrickel,

Florian Läng

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000369706

Subject(s) - ampk , connexin , protein kinase a , pressure overload , medicine , endocrinology , chemistry , microbiology and biotechnology , amp activated protein kinase , gap junction , phosphorylation , biology , muscle hypertrophy , intracellular , cardiac hypertrophy

Adenosine 5'-monophosphate (AMP)-activated protein kinase (Ampk) modulates a wide array of cellular functions and regulates various ion channels and transporters. In failing human hearts an increased Ampkα1 activity was observed. The present study aimed to uncover the impact of Ampkα1 on cardiac electrical remodeling.

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