Olopatadine Inhibits Exocytosis in Rat Peritoneal Mast Cells by Counteracting Membrane Surface Deformation | Zendy

Asuka Baba | Zendy; Masahiro Tachi | Zendy; Yoshio Maruyama | Zendy; Itsuro Kazama | Zendy

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Olopatadine Inhibits Exocytosis in Rat Peritoneal Mast Cells by Counteracting Membrane Surface Deformation

Author(s) -

Asuka Baba,

Masahiro Tachi,

Yoshio Maruyama,

Itsuro Kazama

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000369704

Subject(s) - exocytosis , mast cell , biophysics , microbiology and biotechnology , membrane , histamine , chemistry , pharmacology , biology , immunology , biochemistry

Besides its anti-allergic properties as a histamine receptor antagonist, olopatadine stabilizes mast cells by inhibiting the release of chemokines. Since olopatadine bears amphiphilic features and is preferentially partitioned into the lipid bilayers of the plasma membrane, it would induce some morphological changes in mast cells and thus affect the process of exocytosis.

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