Hyperketonemia (Acetoacetate) Upregulates NADPH Oxidase 4 and Elevates Oxidative Stress, ICAM-1, and Monocyte Adhesivity in Endothelial Cells | Zendy

Preeti Kanikarla Marie | Zendy; Sushil K. Jain | Zendy

Open Access

Hyperketonemia (Acetoacetate) Upregulates NADPH Oxidase 4 and Elevates Oxidative Stress, ICAM-1, and Monocyte Adhesivity in Endothelial Cells

Author(s) -

Preeti Kanikarla Marie,

Sushil K. Jain

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000369702

Subject(s) - oxidative stress , nox4 , nadph oxidase , monocyte , downregulation and upregulation , endothelial dysfunction , icam 1 , chemistry , gene knockdown , medicine , endocrinology , pharmacology , biochemistry , immunology , cell adhesion molecule , apoptosis , gene

The incidence of developing microvascular dysfunction is significantly higher in type 1 diabetic (T1D) patients. Hyperketonemia (acetoacetate, β-hydroxybutyrate) is frequently found along with hyperglycemia in T1D. Whether hyperketonemia per se contributes to the excess oxidative stress and cellular injury observed in T1D is not known.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research