Ezrin/Exocyst Complex Regulates Mucin 5AC Secretion Induced by Neutrophil Elastase in Human Airway Epithelial Cells | Zendy

Qi Li | Zendy; Na Li | Zendy; Chunyi Liu | Zendy; Rui Xu | Zendy; Victor P. Кolosov | Zendy; Juliy M. Perelman | Zendy; Xiangdong Zhou | Zendy

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Ezrin/Exocyst Complex Regulates Mucin 5AC Secretion Induced by Neutrophil Elastase in Human Airway Epithelial Cells

Author(s) -

Qi Li,

Na Li,

Chunyi Liu,

Rui Xu,

Victor P. Кolosov,

Juliy M. Perelman,

Xiangdong Zhou

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000369699

Subject(s) - ezrin , mucin , secretion , microbiology and biotechnology , transfection , chemistry , biology , cell , cytoskeleton , biochemistry , gene

Increased mucin secretion is a characteristic feature of many chronic airway diseases, particularly during periods of exacerbation; however, the exact mechanism of mucin secretion remains unclear. Ezrin, which is a specific marker of apical membranes, is predominantly concentrated in exocyst-rich cell surface structures, crosslinking the actin cytoskeleton with the plasma membrane. In the present study, we examined whether Ezrin is involved in mucin 5AC (MUC5AC) secretion after neutrophil elastase (NE) attack, and we investigated the role of the exocyst complex docking protein Sec3 in this process.

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