Electrophysiological Characteristics of Embryonic Stem Cell-Derived Cardiomyocytes are Cell Line-Dependent
Author(s) -
Tobias Hannes,
Marie Wolff,
Michael Xavier Doss,
Kurt Pfannkuche,
Moritz Haustein,
Jochen MüllerEhmsen,
Agapios Sachinidis,
Jürgen Hescheler,
Markus Khalil,
Marcel Halbach
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000369697
Subject(s) - embryonic stem cell , puromycin , electrophysiology , microbiology and biotechnology , cell culture , biology , cellular differentiation , green fluorescent protein , transgene , neuroscience , genetics , gene , protein biosynthesis
Modelling of cardiac development, physiology and pharmacology by differentiation of embryonic stem cells (ESCs) requires comparability of cardiac differentiation between different ESC lines. To investigate whether the outcome of cardiac differentiation is consistent between different ESC lines, we compared electrophysiological properties of ESC-derived cardiomyocytes (ESC-CMs) of different murine ESC lines.
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