AMP-Activated Protein Kinase Alleviates Extracellular Matrix Accumulation in High Glucose-Induced Renal Fibroblasts through mTOR Signaling Pathway | Zendy

Xia Luo | Zendy; Lingyan Deng | Zendy; Laxmi Pangeni Lamsal | Zendy; Wenjuan Xu | Zendy; Xiang Cheng | Zendy; Liming Cheng | Zendy

Open Access

AMP-Activated Protein Kinase Alleviates Extracellular Matrix Accumulation in High Glucose-Induced Renal Fibroblasts through mTOR Signaling Pathway

Author(s) -

Xia Luo,

Lingyan Deng,

Laxmi Pangeni Lamsal,

Wenjuan Xu,

Xiang Cheng,

Liming Cheng

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000369687

Subject(s) - ampk , pi3k/akt/mtor pathway , microbiology and biotechnology , extracellular matrix , signal transduction , protein kinase a , amp activated protein kinase , mtorc1 , phosphorylation , chemistry , extracellular , biology

Extracellular matrix accumulation contributes significantly to the pathogenesis of diabetic nephropathy. Although AMP-activated protein kinase (AMPK) has been found to inhibit extracellular matrix synthesis by experiments in vivo and vitro, its role in alleviating the deposition of extracellular matrix in renal interstitial fibroblasts has not been well defined.

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