Increased Levels of Type 1 Interferon in a Type 1 Diabetic Mouse Model Induce the Elimination of B Cells from the Periphery by Apoptosis and Increase their Retention in the Spleen | Zendy

Badr Mohamed Badr | Zendy; Nadia Moustafa | Zendy; Heba M. Saad Eldien | Zendy; Amany O. Mohamed | Zendy; Hany M. Ibrahim | Zendy; Ibrahim El-Elaimy | Zendy; Mohamed H. Mahmoud | Zendy; Gamal Badr | Zendy

Open Access

Increased Levels of Type 1 Interferon in a Type 1 Diabetic Mouse Model Induce the Elimination of B Cells from the Periphery by Apoptosis and Increase their Retention in the Spleen

Author(s) -

Badr Mohamed Badr,

Nadia Moustafa,

Heba M. Saad Eldien,

Amany O. Mohamed,

Hany M. Ibrahim,

Ibrahim El-Elaimy,

Mohamed H. Mahmoud,

Gamal Badr

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000369682

Subject(s) - endocrinology , medicine , streptozotocin , apoptosis , dyslipidemia , immune system , type 1 diabetes , interferon , receptor , diabetes mellitus , insulin , spleen , immunology , biology , biochemistry

The autoimmune disease type 1 diabetes mellitus (T1D) is associated with a defect in the immune response, which increases susceptibility to infection. We recently demonstrated that prolonged elevated levels of type 1 interferon (IFN) induce lymphocyte exhaustion during T1D.

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