Open AccessRapamycin Attenuates Aldosterone-Induced Tubulointerstitial Inflammation and Fibrosis
Author(s) -
Bin Wang,
Wei Ding,
Minmin Zhang,
Hongmei Li,
Yong Gu
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000369680
Subject(s) - fibrosis , inflammation , fibronectin , endocrinology , medicine , extracellular matrix , western blot , pi3k/akt/mtor pathway , chemistry , biology , signal transduction , microbiology and biotechnology , biochemistry , gene
Aldosterone (Aldo), a mediator of kidney fibrosis, is implicated in the pathogenesis of chronic kidney diseases (CKD). The aim of this study was to evaluate the regulatory role of rapamycin (Rap) in Aldo-induced tubulointerstitial inflammation and fibrosis.
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