Leptin Rapidly Induces the Expression of Metabolic and Myokine Genes in C2C12 Muscle Cells to Regulate Nutrient Partition and Oxidation | Zendy

Yuriy Nozhenko | Zendy; Ana M. Rodríguez | Zendy; Andreu Palou | Zendy

Open Access

Leptin Rapidly Induces the Expression of Metabolic and Myokine Genes in C2C12 Muscle Cells to Regulate Nutrient Partition and Oxidation

Author(s) -

Yuriy Nozhenko,

Ana M. Rodríguez,

Andreu Palou

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000369678

Subject(s) - pdk4 , ucp3 , leptin , endocrinology , medicine , myogenesis , skeletal muscle , biology , leptin receptor , uncoupling protein , peroxisome proliferator activated receptor , ppargc1a , myokine , adiponectin receptor 1 , coactivator , nrf1 , mitochondrial biogenesis , receptor , insulin , gene expression , adiponectin , microbiology and biotechnology , mitochondrion , adipose tissue , insulin resistance , biochemistry , gene , transcription factor , obesity , brown adipose tissue

Skeletal muscle can experience pronounced metabolic adaptations in response to extrinsic stimuli, and expresses leptin receptor (OB-Rb). We aimed to further the understanding of leptin effects on muscle cells, by studying the expression of key energy metabolism genes in C2C12 myotubes.

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