Stimulation of Erythrocyte Death by Phloretin | Zendy

Rosi Bissinger | Zendy; Salome Hannah Fischer | Zendy; Kashif Jilani | Zendy; Florian Läng | Zendy

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Stimulation of Erythrocyte Death by Phloretin

Author(s) -

Rosi Bissinger,

Salome Hannah Fischer,

Kashif Jilani,

Florian Läng

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000369668

Subject(s) - phloretin , phosphatidylserine , protein kinase c , ceramide , staurosporine , protein kinase a , chemistry , biochemistry , diacylglycerol kinase , extracellular , microbiology and biotechnology , kinase , phospholipid , apoptosis , biology , membrane

Phloretin, a natural component of apples, pears and strawberries, has previously been shown to stimulate apoptosis of nucleated cells. Erythrocytes may similarly enter suicidal death or eryptosis, which is characterized by cell shrinkage and phospholipid scrambling of the erythrocyte cell membrane with phosphatidylserine translocation to the erythrocyte surface. Stimulators of eryptosis include increase of cytosolic Ca(2+)-activity ([Ca(2+)]i), ceramide, ATP depletion, and activation of protein kinase C (PKC) as well as p38 mitogen activated protein kinase (p38 kinase).

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