Trimetazidine Protects Umbilical Cord Mesenchymal Stem Cells Against Hypoxia and Serum Deprivation Induced Apoptosis by Activation of Akt | Zendy

Xuhe Gong | Zendy; Guangpu Fan | Zendy; Wei Wang | Zendy; Guogan Wang | Zendy

Open Access

Trimetazidine Protects Umbilical Cord Mesenchymal Stem Cells Against Hypoxia and Serum Deprivation Induced Apoptosis by Activation of Akt

Author(s) -

Xuhe Gong,

Guangpu Fan,

Wei Wang,

Guogan Wang

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000369667

Subject(s) - umbilical cord , hypoxia (environmental) , mesenchymal stem cell , apoptosis , trimetazidine , protein kinase b , stem cell , pi3k/akt/mtor pathway , medicine , microbiology and biotechnology , cancer research , endocrinology , andrology , biology , immunology , chemistry , biochemistry , organic chemistry , oxygen

Mesenchymal stem cell (MSC) transplantation is a promising therapy for cardiac repair. However, the efficacy is limited by the poor viability of MSCs in the infarcted heart. Recent findings have implicated that trimetazidine (TMZ) enhanced the survival of the stem cells under various conditions. However, as the stem cells in these studies were animal-derived, little information is available about the effects of TMZ on human MSCs. Herein, we propose that TMZ may protect human MSCs against apoptosis induced by Hypoxia/Serum deprivation (H/SD).

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