Decreased Maternal Serum 2-Methoxyestradiol Levels are Associated with the Development of Preeclampsia | Zendy

Zhijun Shen | Zendy; Yanming Wu | Zendy; Chen Xiao | Zendy; Xinwen Chang | Zendy; Qian Zhou | Zendy; Jian Zhou | Zendy; Hao Ying | Zendy; Jing Zheng | Zendy; Tao Duan | Zendy; Kai Wang | Zendy

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Decreased Maternal Serum 2-Methoxyestradiol Levels are Associated with the Development of Preeclampsia

Author(s) -

Zhijun Shen,

Yanming Wu,

Chen Xiao,

Xinwen Chang,

Qian Zhou,

Jian Zhou,

Hao Ying,

Jing Zheng,

Tao Duan,

Kai Wang

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000369662

Subject(s) - 2 methoxyestradiol , preeclampsia , cell growth , western blot , catechol o methyl transferase , andrology , trophoblast , endocrinology , placental growth factor , placenta , oxidative stress , medicine , chemistry , hypoxia (environmental) , pregnancy , biology , metabolite , fetus , biochemistry , oxygen , allele , organic chemistry , gene , genetics

2-methoxyestradiol (2-ME), a natural metabolite of 17β-estradiol, is synthesized by catechol-O-methyltransferase (COMT). The aim of this study was to explore the maternal 2-ME concentration and placental COMT expression in the different trimesters of normal pregnancy and preeclamptic pregnancies, as well as the effects of 2-ME on cell proliferation and migration of HTR-8/SVneo under normoxic (20% O2) and hypoxic (2.5% O2) conditions.

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