TGF-�1 Promotes Osteosarcoma Cell Migration and Invasion Through the miR-143-Versican Pathway | Zendy

Fengfeng Li | Zendy; Shaohua Li | Zendy; Cheng Tao | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

TGF-�1 Promotes Osteosarcoma Cell Migration and Invasion Through the miR-143-Versican Pathway

Author(s) -

Fengfeng Li,

Shaohua Li,

Cheng Tao

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000369660

Subject(s) - versican , smad , gene knockdown , osteosarcoma , cancer research , cell migration , chemistry , cell , transforming growth factor , microbiology and biotechnology , biology , cell culture , extracellular matrix , proteoglycan , biochemistry , genetics

TGF-β1 is an abundant cytokine present in the tumour microenvironment. It has been shown to trigger versican expression in human osteosarcoma cells, which may account for the metastatic potential of these cells. However, the underlying mechanism of TGF-β1-mediated metastasis remains unclear. The aim of this study was to evaluate the roles of versican in TGF-β1-induced osteosarcoma cell migration and invasion.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research