Melatonin Protects the Esophageal Epithelial Barrier by Suppressing the Transcription, Expression and Activity of Myosin Light Chain Kinase Through ERK1/2 Signal Transduction | Zendy

Jiacheng Tan | Zendy; Ying Wang | Zendy; Yang Xia | Zendy; Nina Zhang | Zendy; Xiaomeng Sun | Zendy; Ting Yu | Zendy; Lin Lin | Zendy

Open Access

Melatonin Protects the Esophageal Epithelial Barrier by Suppressing the Transcription, Expression and Activity of Myosin Light Chain Kinase Through ERK1/2 Signal Transduction

Author(s) -

Jiacheng Tan,

Ying Wang,

Yang Xia,

Nina Zhang,

Xiaomeng Sun,

Ting Yu,

Lin Lin

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000369656

Subject(s) - myosin light chain kinase , signal transduction , melatonin , microbiology and biotechnology , myosin , kinase , chemistry , transcription factor , biology , endocrinology , biochemistry , gene

Dilated intercellular space (DIS) contributes to the pathophysiology of gastroesophageal reflux disease (GERD). Melatonin protects the esophageal mucosa; however, the mechanisms underlying that protection remain unclear.

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