Combination Therapy with Telmisartan and Oxacalcitriol Suppresses the Progression of Murine Adriamycin Nephropathy
Author(s) -
Kyung Hwan Jeong,
Katsuhiko Asanuma,
Aida Lydia,
Miyuki Takagi,
Rin Asao,
Fumiko Kodama,
Etsuko Asanuma,
Yasuhiko Tomino
Publication year - 2015
Publication title -
the nephron journals/nephron journals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.951
H-Index - 72
eISSN - 2235-3186
pISSN - 1660-8151
DOI - 10.1159/000369346
Subject(s) - medicine , telmisartan , nephrin , podocin , glomerulosclerosis , podocyte , albuminuria , endocrinology , diabetic nephropathy , nephropathy , valsartan , irbesartan , angiotensin ii , pharmacology , kidney , blood pressure , proteinuria , diabetes mellitus
Blockade of the renin-angiotensin system plays a key role in suppressing the progression of renal diseases. It has not been well established whether this therapy provides additional effects when combined with vitamin D or its analog in a model of adriamycin (ADR)-induced nephropathy.
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