The Tumor Necrosis Factor Superfamily Members TWEAK, TNFSF15 and Fibroblast Growth Factor-Inducible Protein 14 Are Upregulated in Proliferative Diabetic Retinopathy | Zendy

Ahmed M. Abu ElAsrar | Zendy; Gert De Hertogh | Zendy; Mohd Imtiaz Nawaz | Zendy; Mohammad Mairaj Siddiquei | Zendy; Kathleen Van den Eynde | Zendy; Ghulam Mohammad | Zendy; Ghislain Opdenakker | Zendy; Karel Geboes | Zendy

Open Access

The Tumor Necrosis Factor Superfamily Members TWEAK, TNFSF15 and Fibroblast Growth Factor-Inducible Protein 14 Are Upregulated in Proliferative Diabetic Retinopathy

Author(s) -

Ahmed M. Abu ElAsrar,

Gert De Hertogh,

Mohd Imtiaz Nawaz,

Mohammad Mairaj Siddiquei,

Kathleen Van den Eynde,

Ghulam Mohammad,

Ghislain Opdenakker,

Karel Geboes

Publication year - 2015

Publication title -

ophthalmic research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.893

H-Index - 54

eISSN - 1423-0259

pISSN - 0030-3747

DOI - 10.1159/000369300

Subject(s) - tumor necrosis factor alpha , inflammation , western blot , biology , vascular endothelial growth factor , neovascularization , microbiology and biotechnology , diabetic retinopathy , immunology , angiogenesis , cancer research , endocrinology , diabetes mellitus , biochemistry , vegf receptors , gene

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and tumor necrosis factor superfamily member 15 (TNFSF15), members of the TNF superfamily, play important roles in the modulation of inflammation and neovascularization. TWEAK activity is mediated via binding to fibroblast growth factor-inducible molecule 14 (Fn14). We investigated the expression of TWEAK, Fn14 and TNFSF15 and the correlation between TWEAK levels and the levels of the inflammatory biomarker soluble intercellular adhesion molecule-1 (sICAM-1) in proliferative diabetic retinopathy (PDR). In addition, we examined the expression of FN14 and TNFSF15 in retinas of diabetic rats.

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