Genetic and Biological Effects of Sodium-Chloride Cotransporter (SLC12A3) in Diabetic Nephropathy | Zendy

Norhashimah Abu Seman | Zendy; Bing He | Zendy; Juha Ojala | Zendy; Wan Nazaimoon Wan Mohamud | Zendy; Claes-GFran Östenson | Zendy; Kerstin Brismar | Zendy; Harvest F. Gu | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Genetic and Biological Effects of Sodium-Chloride Cotransporter (<b><i>SLC12A3</i></b>) in Diabetic Nephropathy

Author(s) -

Norhashimah Abu Seman,

Bing He,

Juha Ojala,

Wan Nazaimoon Wan Mohamud,

Claes-GFran Östenson,

Kerstin Brismar,

Harvest F. Gu

Publication year - 2014

Publication title -

american journal of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 85

eISSN - 1421-9670

pISSN - 0250-8095

DOI - 10.1159/000368916

Subject(s) - endocrinology , medicine , diabetic nephropathy , gene knockdown , allele , biology , diabetes mellitus , genetics , gene

Solute carrier family 12 member 3 (SLC12A3) encodes a sodium/chloride transporter in kidneys. Previous reports suggest that Arg913Gln polymorphism in this gene is associated with diabetic nephropathy (DN), but the data appear to be inconsistent. Up to now, there is no biological evidence concerning the effects of SLC12A3 in DN. In this study, we aim to evaluate the genetic effects of the SLC12A3 gene and its Arg913Gln polymorphism with genetic and functional analyses.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research