Lipin Family Proteins - Key Regulators in Lipid Metabolism
Author(s) -
Yi Chen,
Bei-bei Rui,
Liying Tang,
Chengmu Hu
Publication year - 2014
Publication title -
annals of nutrition and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.926
H-Index - 81
eISSN - 1421-9697
pISSN - 0250-6807
DOI - 10.1159/000368661
Subject(s) - lipid metabolism , biology , metabolism , microbiology and biotechnology , biochemistry , phosphatidate , regulation of gene expression , gene expression , gene , enzyme , diacylglycerol kinase , protein kinase c
Proteins in the lipin family play a key role in lipid synthesis due to their phosphatidate phosphatase activity, and they also act as transcriptional coactivators to regulate the expression of genes involved in lipid metabolism. The lipin family includes three members, lipin1, lipin2, and lipin3, which exhibit tissue-specific expression, indicating that they may have distinct roles in mediating disease. To date, most studies have focused on lipin1, whereas the roles of lipin2 and lipin3 are less understood.
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