Neurogenesis in the Normal Ageing Hippocampus: A Mini-Review | Zendy

Désirée R. Seib | Zendy; Ana MartinVillalba | Zendy

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Neurogenesis in the Normal Ageing Hippocampus: A Mini-Review

Author(s) -

Désirée R. Seib,

Ana MartinVillalba

Publication year - 2014

Publication title -

gerontology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.397

H-Index - 94

eISSN - 1423-0003

pISSN - 0304-324X

DOI - 10.1159/000368575

Subject(s) - neurogenesis , dentate gyrus , neuroscience , hippocampus , neural stem cell , ageing , cognitive decline , cognition , biology , psychology , stem cell , medicine , dementia , microbiology and biotechnology , disease , genetics

New neurons are continuously generated and added to neural circuits in the adult brain. However, increasing age imposes changes in neural progenitor cells and their microenvironment that lead to a reduction of neurogenesis. Age-related decreased production of new neurons in the neurogenic dentate gyrus has been associated with memory impairments. Several mechanisms are known that might counteract this decline in cognitive functions. Here, we give an overview of ageing-related changes in neurogenesis in the brain of humans and rodents. We discuss possible causes for reduced neurogenesis with age, its consequences on cognition, and how neurogenesis might be restored in old age.

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