The Intron 4 Polymorphism in the Calcium-Sensing Receptor Gene in Diabetes Mellitus and its Chronic Complications, Diabetic Nephropathy and Non-Diabetic Renal Disease | Zendy

Viera Železníková | Zendy; Marcela Vedralová | Zendy; Anna Kotrbová-Kozak | Zendy; H Zoubková | Zendy; Marie Černá | Zendy; Ivan Rychlík | Zendy

Open Access

The Intron 4 Polymorphism in the Calcium-Sensing Receptor Gene in Diabetes Mellitus and its Chronic Complications, Diabetic Nephropathy and Non-Diabetic Renal Disease

Author(s) -

Viera Železníková,

Marcela Vedralová,

Anna Kotrbová-Kozak,

H Zoubková,

Marie Černá,

Ivan Rychlík

Publication year - 2014

Publication title -

kidney and blood pressure research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.806

H-Index - 51

eISSN - 1423-0143

pISSN - 1420-4096

DOI - 10.1159/000368453

Subject(s) - diabetic nephropathy , medicine , kidney disease , endocrinology , diabetes mellitus , pathogenesis , nephropathy , calcium sensing receptor , kidney , parathyroid hormone , calcium

Calcium-Sensing Receptor (CaSR) significantly affects calcium-phosphate metabolism in kidneys, and it is implicated in the pathogenesis of diabetes mellitus (DM) due to its expression in pancreatic β-cells. The role of CaSR as one of the players in pathogenesis of chronic kidney disease (CKD) has been speculated.

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