p16 Gene Transfer Induces Centrosome Amplification and Abnormal Nucleation Associated with Survivin Downregulation in Glioma Cells | Zendy

Takeshi Takayasu | Zendy; Seiji Hama | Zendy; Fumiyuki Yamasaki | Zendy; Taiichi Saito | Zendy; Yosuke Watanabe | Zendy; Ryo Nosaka | Zendy; Kazuhiko Sugiyama | Zendy; Kaoru Kurisu | Zendy

Open Access

p16 Gene Transfer Induces Centrosome Amplification and Abnormal Nucleation Associated with Survivin Downregulation in Glioma Cells

Author(s) -

Takeshi Takayasu,

Seiji Hama,

Fumiyuki Yamasaki,

Taiichi Saito,

Yosuke Watanabe,

Ryo Nosaka,

Kazuhiko Sugiyama,

Kaoru Kurisu

Publication year - 2015

Publication title -

pathobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.941

H-Index - 53

eISSN - 1423-0291

pISSN - 1015-2008

DOI - 10.1159/000368196

Subject(s) - centrosome , survivin , microbiology and biotechnology , biology , cancer research , chromosome instability , mitosis , radiosensitivity , cell cycle , chemistry , cell culture , cell , chromosome , gene , genetics , medicine , radiation therapy

In human glioma cells, p16 gene transfer induced G1/S arrest, increased radiosensitivity and abnormal nucleation (especially bi- and multinucleation). Survivin suppression caused G2/M arrest, radiosensitization and an increase in aneuploidy accompanied by centrosome amplification. Abnormal nucleation and aneuploidy represent chromosome instability (CIN), and it is well known that centrosome amplification leads to CIN. However, little has been reported that suggests that transferring p16 causes centrosome overduplication during the G1/S phase.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research