Staphylococcal Exotoxins Induce Interleukin 22 in Human Th22 Cells | Zendy

Margarete Niebuhr | Zendy; Julia Mainardy | Zendy; Annice Heratizadeh | Zendy; Imke Satzger | Zendy; Thomas Werfel | Zendy

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Staphylococcal Exotoxins Induce Interleukin 22 in Human Th22 Cells

Author(s) -

Margarete Niebuhr,

Julia Mainardy,

Annice Heratizadeh,

Imke Satzger,

Thomas Werfel

Publication year - 2014

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000367923

Subject(s) - exotoxin , immunology , interleukin 22 , memory t cell , interleukin 21 , enterotoxin , t cell , biology , superantigen , interleukin , microbiology and biotechnology , toxin , medicine , cytokine , immune system , biochemistry , escherichia coli , gene

We have shown previously that T cells from atopic dermatitis (AD) patients produce more IL-22 upon staphylococcal exotoxin stimulation compared to psoriasis patients and healthy controls. The role of staphylococcal exotoxins on polarized memory T helper (Th)22 cells which are enriched in inflamed AD skin remains elusive. Our aim was to investigate IL-22 production in response to staphylococcal enterotoxin B (SEB) and α-toxin stimulation in human memory T cells and polarized Th22 cells.

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