Flk-1/KDR Mediates Ethanol-Stimulated Endothelial Cell Notch Signaling and Angiogenic Activity | Zendy

D. John Morrow | Zendy; Ekaterina Hatch | Zendy; Katie Hamm | Zendy; Paul A. Cahill | Zendy; Eileen M. Redmond | Zendy

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Flk-1/KDR Mediates Ethanol-Stimulated Endothelial Cell Notch Signaling and Angiogenic Activity

Author(s) -

D. John Morrow,

Ekaterina Hatch,

Katie Hamm,

Paul A. Cahill,

Eileen M. Redmond

Publication year - 2014

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000367807

Subject(s) - notch signaling pathway , angiogenesis , endocrinology , signal transduction , notch 1 , gene knockdown , microbiology and biotechnology , medicine , vascular endothelial growth factor a , biology , chemistry , matrigel , endothelial stem cell , vascular endothelial growth factor , cancer research , biochemistry , apoptosis , in vitro , vegf receptors

We previously reported that ethanol (EtOH) stimulates endothelial angiogenic activity mediated via a notch- and angiopoietin-1 (Ang-1) pathway. As crosstalk exists between notch and vascular endothelial growth factor (VEGF) signaling, we examined whether the VEGF receptor (VEGFR) Flk-1 (fetal liver kinase 1) mediates EtOH-stimulated notch signaling and angiogenic activity.

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