Ouabain Increases Gap Junctional Communication in Epithelial Cells | Zendy

Arturo Ponce | Zendy; Isabel Larré | Zendy; Aída Castillo | Zendy; Refugio GarcíaVillegas | Zendy; Adrián Romero | Zendy; Catalina Flores-Maldonado | Zendy; Jacqueline MartínezRendón | Zendy; R. Contreras | Zendy; Marcelino Cereijido | Zendy

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Ouabain Increases Gap Junctional Communication in Epithelial Cells

Author(s) -

Arturo Ponce,

Isabel Larré,

Aída Castillo,

Refugio GarcíaVillegas,

Adrián Romero,

Catalina Flores-Maldonado,

Jacqueline MartínezRendón,

R. Contreras,

Marcelino Cereijido

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000366403

Subject(s) - ouabain , gap junction , microbiology and biotechnology , cycloheximide , biology , cell , cell culture , chemistry , endocrinology , medicine , biochemistry , intracellular , sodium , genetics , organic chemistry

The finding that endogenous ouabain acts as a hormone prompted efforts to elucidate its physiological function. In previous studies, we have shown that 10 nM ouabain (i.e., a concentration within the physiological range) modulates cell-cell contacts such as tight junctions and apical/basolateral polarity. In this study, we examined whether 10 nM ouabain affects another important cell-cell feature: gap junction communication (GJC).

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