CYC1 Silencing Sensitizes Osteosarcoma Cells to TRAIL-Induced Apoptosis | Zendy

Guodong Li | Zendy; Dong Fu | Zendy; Wenqing Liang | Zendy; Lin Fan | Zendy; Kai Chen | Zendy; Liancheng Shan | Zendy; Shuo Hu | Zendy; Xiaojun Ma | Zendy; Ke Zhou | Zendy; Biao Cheng | Zendy

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CYC1 Silencing Sensitizes Osteosarcoma Cells to TRAIL-Induced Apoptosis

Author(s) -

Guodong Li,

Dong Fu,

Wenqing Liang,

Lin Fan,

Kai Chen,

Liancheng Shan,

Shuo Hu,

Xiaojun Ma,

Ke Zhou,

Biao Cheng

Publication year - 2014

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000366402

Subject(s) - gene silencing , apoptosis , cancer research , carcinogenesis , small hairpin rna , cell growth , cell culture , in vivo , osteosarcoma , cytochrome c , biology , transfection , microbiology and biotechnology , chemistry , gene knockdown , cancer , biochemistry , genetics , gene

Osteosarcoma (OS) is an aggressive bone malignancy with poor prognosis. Many OS cells are resistant to apoptotic induction by tumor necrosis factor-related apoptosis inducing ligand (TRAIL). In our previous study, we found that the serum level of cytochrome c1 (CYC1) is significantly higher in OS patients than in healthy subjects. Our aim was to investigate the effects of CYC1 silencing on TRAIL-induced apoptosis in human OS in vitro and in vivo along with the underlying mechanisms.

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